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Cushing's disease is a condition in which the adrenal glands overproduce certain hormones. There are three types of Cushing's disease, each of which has a different cause. The most common cause of Cushing's disease is a pituitary gland tumor. Cushing's disease may also be the result of a benign or malignant tumor of the adrenal gland itself, or may be caused from the excessive administration of an oral or injectable steroid. Clinical signs, treatment, and prognosis are discussed.
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Cushing's disease, or hyperadrenocorticism, is the overproduction of cortisol hormone by a dog's body. The clinical signs of Cushing's disease are similar, regardless of the underlying cause of the disease. However, it is essential to identify the type of Cushing's disease as the treatment and prognosis differ slightly depending upon the form of the disease.
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Treatment for Cushing’s disease using mitotane involves two phases: initiating phase and maintenance phase. Monitoring your dog’s food and water intake is very important. This handout provides detailed treatment instructions for dogs prescribed mitotane. Follow your veterinarian’s instructions carefully and report changes in your dog’s behavior to your veterinarian.
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A cutaneous histiocytoma is a common benign (harmless) tumor of the skin in dogs, typically younger ones. Their development, appearance, diagnosis, and treatment are explained in this handout.
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Cutaneous histiocytosis is an uncommon condition in dogs. It is a non-cancerous increase in the number of reactive cells (histiocytes) caused by an immune system dysfunction. It generally manifests as multiple bumps and nodules confined to the dog's skin. The clinical signs, diagnosis, and treatment of this condition are explained in this handout.
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Systemic lymphoma is a very common cancer in dogs, but the cutaneous form is quite rare. Current statistics suggest that cutaneous lymphoma accounts for only about 5% of canine lymphoma cases. The disease can present in a variety of lesions, including ulcers, nodules, red patches, and areas of hair loss and skin scaling. Because not very much is known about canine cutaneous lymphoma, there are no standard treatment protocols and the prognosis is poor.
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Cuterebra are botflies that spend the larvae stage of their lifecycle within rodent or rabbit hosts and can accidentally infect dogs. They enter through the nose, mouth or a skin wound. They usually develop a cyst under the skin that can be located as it enlarges and often a breathing hole can be seen. The larva (warble) will leave the dog when it is ready to form a pupa but it will often leave behind a secondary bacterial skin infection or abscess in the empty cyst. Rarely, the larva/cuterebra migrate aberrantly through the dog causing inflammation and damage to different tissues, including the brain and eyes, and even potentially cause a severe systemic inflammatory response. Treatment depends on what damage has been done and can include removal of the warble, debridement or removal of the cyst, antibiotics and symptomatic and supportive treatment of the results of aberrant migration. Prognosis is generally good if only the skin is involved. Cuterebra infection can not be prevented easily, so monitoring the dog regularly for signs is important.
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Blue-green algae, also called cyanobacteria, are found in fresh and brackish water of ponds and lakes. These microscopic bacteria can also grow in backyard fountains, garden pots, bird baths, and anywhere water is stagnant. Regardless of where they are found, cyanobacteria can be dangerous.
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Cyanocobalamin (vitamin B12 or cobalamin) is a vitamin supplement used to treat systemic deficiencies. It can be given through a subcutaneous injection or oral tablet. The injection may sting temporarily, but otherwise is very safe. If a negative reaction occurs, call your veterinary office.
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Cyanosis is a bluish discoloration of the skin and mucous membranes of the body caused by inadequate oxygen levels. Cyanosis is an emergency, and the root cause may be life-threatening and may or may not be reversible. Once back home, homecare instructions must be followed carefully.